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Anti SHOC2 | Gentaur

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SKU:
137-GWB-MX338E-GEN
Availability:
IN STOCK
$340
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Description

Anti SHOC2 | 137-GWB-MX338E

Description:

Rabbit polyclonal to Shoc2

Host species:

Rabbit

Species reactivity:

Human

Immunogen:

A 21 amino acid peptide near the N terminus of Human Shoc2/ Sur8 (NP_031399).

Positive control:

Jurkat cell lysate; Human spleen tissue

Form:

Liquid

Storage instructions:

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer:

  • pH: 7.2
  • Preservative: 0.02% Sodium azide
  • Constituent: PBS

Concentration:

100 µg at 1 mg/ml

Purity:

Immunogen affinity purified

Clonality:

Polyclonal

Isotype:

IgG

Function:

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

Involvement in disease:

Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH). NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.

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Additional Information

Size:
100 µg
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